Article
Association of soluble CD40 levels with -1 C > T CD40 polymorphism and chronic kidney disease in systemic lupus erythematosus.
Molecular genetics & genomic medicine - 1 Dec 2019
Tapia-Llanos Raziel, Muñoz-Valle José F, Román-Fernández Ilce V, Marín-Rosales Miguel, Salazar-Camarena Diana C, Cruz Alvaro, Orozco-Barocio Gerardo, Guareña-Casillas Jorge A, Oregon-Romero Edith, Palafox-Sánchez Claudia A
Abstract excerpt
BACKGROUND: CD40 is a transmembrane protein mainly expressed on the antigen-presenting cells surface. CD40 plays a crucial role in immunoglobulin class switching and antibodies production. Genetic polymorphisms in the CD40 gene have been associated with increased risk of systemic lupus erythematosus (SLE) in several populations. This study aimed to evaluate the association of CD40 polymorphisms (-1 C > T,...
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