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Article

Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic children.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Mar 2009

Chan Iris H S, Tang Nelson L S, Leung Ting F, Huang W, Lam Yvonne Y O, Wong Gary W K, Chan Juliana C N, Chan Michael H M, Wong Chun K, Zhang Ya P, Lam Christopher W K

Abstract excerpt

Early growth response-1 (Egr-1) is expressed in human airways and found to modulate tumor necrosis factor, immunoglobulin E (IgE), airway responsiveness, and interleukin-13-induced inflammation in mice. We investigated the effects of Chinese-tagging single nucleotide polymorphisms (SNPs) of Egr-1 on asthma traits in 298 Chinese asthmatic children and 175 controls, and a replication community cohort of 191...

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PMID: 18507785
DOI: 10.1111/j.1399-3038.2008.00757.x

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