Article
Curvature of clathrin-coated pits driven by epsin.
Nature - 26 Sept 2002
Ford Marijn G J, Mills Ian G, Peter Brian J, Vallis Yvonne, Praefcke Gerrit J K, Evans Philip R, McMahon Harvey T
Abstract excerpt
Clathrin-mediated endocytosis involves cargo selection and membrane budding into vesicles with the aid of a protein coat. Formation of invaginated pits on the plasma membrane and subsequent budding of vesicles is an energetically demanding process that involves the cooperation of clathrin with many different proteins. Here we investigate the role of the brain-enriched protein epsin 1 in this process. Epsin is...
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