Article
Dissecting BAR domain function in the yeast Amphiphysins Rvs161 and Rvs167 during endocytosis.
Molecular biology of the cell - 1 Sept 2010
Youn Ji-Young, Friesen Helena, Kishimoto Takuma, Henne William M, Kurat Christoph F, Ye Wei, Ceccarelli Derek F, Sicheri Frank, Kohlwein Sepp D, McMahon Harvey T, Andrews Brenda J
Abstract excerpt
BAR domains are protein modules that bind to membranes and promote membrane curvature. One type of BAR domain, the N-BAR domain, contains an additional N-terminal amphipathic helix, which contributes to membrane-binding and bending activities. The only known N-BAR-domain proteins in the budding yeast Saccharomyces cerevisiae, Rvs161 and Rvs167, are required for endocytosis. We have explored the mechanism of...
Topics
- Amino Acid Sequence
- Cell Membrane
- Cytoskeletal Proteins
- Endocytosis
- Endosomes
- Green Fluorescent Proteins
- Microfilament Proteins
- Models, Biological
- Molecular Sequence Data
- Mutant Proteins