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Article

Sar1 GTPase Activity Is Regulated by Membrane Curvature.

The Journal of biological chemistry - 15 Jan 2016

Hanna Michael G, Mela Ioanna, Wang Lei, Henderson Robert M, Chapman Edwin R, Edwardson J Michael, Audhya Anjon

Abstract excerpt

The majority of biosynthetic secretory proteins initiate their journey through the endomembrane system from specific subdomains of the endoplasmic reticulum. At these locations, coated transport carriers are generated, with the Sar1 GTPase playing a critical role in membrane bending, recruitment of coat components, and nascent vesicle formation. How these events are appropriately coordinated remains poorly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26546679
DOI: 10.1074/jbc.M115.672287
PMCID: PMC4714187

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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