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Genetic Control of Lithium Sensitivity and Regulation of Inositol Biosynthetic Genes

17 Jun 2010

Abstract excerpt

Lithium (Li(+)) is a common treatment for bipolar mood disorder, a major psychiatric illness with a lifetime prevalence of more than 1%. Risk of bipolar disorder is heavily influenced by genetic predisposition, but is a complex genetic trait and, to date, genetic studies have provided little insight into its molecular origins. An alternative approach is to investigate the genetics of Li(+) sensitivity. Using the...

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PMID: 20567601
DOI: 10.1371/journal.pone.0011151

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