Article
Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures.
Proteins - 15 May 2007
Arai Ryoichi, Ito Kaori, Ohnishi Tetsuo, Ohba Hisako, Akasaka Ryogo, Bessho Yoshitaka, Hanawa-Suetsugu Kyoko, Yoshikawa Takeo, Shirouzu Mikako, Yokoyama Shigeyuki
Abstract excerpt
The human IMPA2 gene, which encodes myo-inositol monophosphatase 2 (IMPA2), is mapped onto 18p11.2, a susceptibility region for bipolar disorder. This chromosomal region has also been proposed to include a susceptibility locus for schizophrenia and febrile seizures. Here we report the crystal structures of human IMPA2 and its complex with calcium and phosphate ions. Human IMPA2 comprises an alpha-beta protein...
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