Article

IMPA1 dependent regulation of plasma membrane phosphatidylinositol 4,5-bisphosphate turnover and calcium signalling by lithium

2022-10-16

Abstract excerpt

Lithium (Li) is a widely used as a mood stabilizer in the clinical management of Bipolar Affective Disorder (BPAD). However, the molecular targets of Li in neural cells that underpin its therapeutic effect remain unresolved. Inositol monophosphatase (IMPA1), is an enzyme involved in the resynthesis of phosphatidylinositol 4,5-bisphosphate (PIP 2 ) following receptor-activated phospholipase C (PLC) signalling. In...

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Identifiers and source

Literature Corpus work: 00114b2a-972c-59cf-80c1-dd3048099242
DOI: 10.1101/2022.10.14.512101

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