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Article

AID expression levels determine the extent of <i>cMyc</i> oncogenic translocations and the incidence of B cell tumor development

4 Aug 2008

Abstract excerpt

Immunoglobulin (Ig) isotype switching is a recombination event that changes the constant domain of antibody genes and is catalyzed by activation-induced cytidine deaminase (AID). Upon recruitment to Ig genes, AID deaminates cytidines at switch (S) recombination sites, leading to the formation of DNA breaks. In addition to their role in isotype switching, AID-induced lesions promote Igh-cMyc chromosomal...

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PMID: 18678733
DOI: 10.1084/jem.20081007

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