Dw14(DRB1*0404) is a Dw4-dependent risk factor for rheumatoid arthritis. Rethinking the "shared epitope" hypothesis.

doi:10.1111/j.1399-0039.1991.tb01888.x

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Article

Dw14(DRB1*0404) is a Dw4-dependent risk factor for rheumatoid arthritis. Rethinking the "shared epitope" hypothesis.

Tissue antigens - 1 Oct 1991

Nelson J L, Mickelson E, Masewicz S, Barrington R, Dugowson C, Koepsell T, Hansen J A

Abstract excerpt

HLA-DR4 has been shown to be associated with risk for developing rheumatoid arthritis (RA) in multiple populations and racial groups. The allelic variants of DR4 share the DR4 serologic specificity but differ by 1 to 3 amino acids in the third hypervariable region (positions 67 to 74) and at posi...

Topics

Alleles
Arthritis, Rheumatoid
Disease Susceptibility
Epitopes
Female
Genetic Predisposition to Disease
Genotype
HLA-D Antigens
Humans
Male
Models, Biological
Pregnancy
Pregnancy Complications
Prospective Studies
Retrospective Studies
Risk
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 1724805
DOI: 10.1111/j.1399-0039.1991.tb01888.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1724805-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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