HLA-DRB1*0401/0404 genotype and rheumatoid arthritis: increased association in men, young age at onset, and disease severity.

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Article

HLA-DRB1*0401/0404 genotype and rheumatoid arthritis: increased association in men, young age at onset, and disease severity.

The Journal of rheumatology - 1 Jun 1995

MacGregor A, Ollier W, Thomson W, Jawaheer D, Silman A

Abstract excerpt

OBJECTIVE: To confirm the reported strong association between the HLA-DRB1*0401/0404 genotype and susceptibility to rheumatoid arthritis (RA), and to investigate the influence of sex, age at disease onset, and variables of disease severity on the strength of this association. METHODS: A case cont...

Topics

Adolescent
Adult
Age of Onset
Alleles
Arthritis, Rheumatoid
Disease Progression
Disease Susceptibility
Female
Genotype
HLA-DR Antigens
HLA-DRB1 Chains
Humans
Male
Middle Aged
Risk Factors
Sex Characteristics

Source

Open in PubMed

Identifiers

PMID: 7674226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7674226-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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