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Article

Association of rheumatoid arthritis with a dominant DR1/Dw4/Dw14 sequence motif, but not with T cell receptor beta chain gene alleles or haplotypes.

Arthritis and rheumatism - 1 Nov 1991

Wallin J, Hillert J, Olerup O, Carlsson B, Ström H

Abstract excerpt

HLA-DR, HLA-DQ, and T cell receptor beta (TCR beta) chain gene polymorphisms were investigated in 43 patients with rheumatoid arthritis (RA), in 10 patients with Felty's syndrome (FS), and in 5 RA multicase families. RA was found to be strongly associated with a DRB1 gene sequence motif present in DR1, DR4-Dw4, and DR4-Dw14 alleles. Ninety-three percent of RA patients were positive for at least 1 of these...

Topics

Alleles
Arthritis, Rheumatoid
Felty Syndrome
Gene Amplification
HLA-DQ Antigens
HLA-DR1 Antigen
HLA-DR4 Antigen
Haplotypes
Humans
Pedigree
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

Receptors, Antigen, T-Cell, alpha-beta

Source

Identifiers

PMID: 1683235
DOI: 10.1002/art.1780341112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1683235-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Association of rheumatoid arthritis with a dominant DR1/Dw4/Dw14 sequence motif, but not with T cell receptor beta chain gene alleles or haplotypes.PMID 1683235Read ↗

Dw14(DRB1*0404) is a Dw4-dependent risk factor for rheumatoid arthritis. Rethinking the "shared epitope" hypothesis.Semantic proximity Read ↗

HLA-DR alleles with naturally occurring amino acid substitutions and risk for development of rheumatoid arthritis.Semantic proximity Read ↗

Immunogenetic heterogeneity in rheumatoid disease as illustrated by different MHC associations (DQ, Dw and C4) in articular and extra-articular subsets.Semantic proximity Read ↗

HLA DMA and DMB show no association with rheumatoid arthritis in US Caucasians.Semantic proximity Read ↗

HLA heterozygosity contributes to susceptibility to rheumatoid arthritis.Semantic proximity Read ↗

Association of HLA-DR4-Dw15 (DRB1*0405) and DR10 with rheumatoid arthritis in a Spanish population.Semantic proximity Read ↗

Association of MHC and rheumatoid arthritis. Association of RA with HLA-DR4: the role of repertoire selection.Semantic proximity Read ↗

HLA-DRB1 alleles and shared amino acid sequences in disease susceptibility and severity in patients from eastern France with rheumatoid arthritis.Semantic proximity Read ↗

Rheumatoid arthritis association in Colombian population is restricted to HLA-DRB1*04 QRRAA alleles.Semantic proximity Read ↗

Rheumatoid arthritis may be primarily associated with HLA-DR4 molecules sharing a particular sequence at residues 67-74.Semantic proximity Read ↗

HLA-DRB1 genotype associations in 793 white patients from a rheumatoid arthritis inception cohort: frequency, severity, and treatment bias.Semantic proximity Read ↗

The association of HLA DR beta alleles with self-limiting and persistent forms of early symmetrical polyarthritis.Semantic proximity Read ↗

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