HLA-DR alleles with naturally occurring amino acid substitutions and risk for development of rheumatoid arthritis.

doi:10.1002/art.1780330704

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Article

HLA-DR alleles with naturally occurring amino acid substitutions and risk for development of rheumatoid arthritis.

Arthritis and rheumatism - 1 Jul 1990

Gao X J, Olsen N J, Pincus T, Stastny P

Abstract excerpt

To determine the HLA-DR4 subtypes associated with rheumatoid arthritis (RA), we performed amplification of DR4 DRB1 genes by the polymerase chain reaction and dot-blots with oligonucleotide probes. In 52 HLA-DR4+ RA patients, Dw4 was the predominant subtype. This subtype was found in 45 of 52 pat...

Topics

Alleles
Arthritis, Rheumatoid
Base Sequence
Genetic Variation
Glycine
HLA-DR Antigens
Humans
Immunoblotting
Molecular Sequence Data
Nucleic Acid Hybridization
Oligonucleotide Probes
Polymerase Chain Reaction

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