Article
HLA heterozygosity contributes to susceptibility to rheumatoid arthritis.
American journal of human genetics - 1 Sept 1992
Wordsworth P, Pile K D, Buckely J D, Lanchbury J S, Ollier B, Lathrop M, Bell J I
Abstract excerpt
We have investigated the role of HLA-DR genotypes in 184 patients with severe rheumatoid arthritis (RA) and in 46 patients with Felty syndrome, to establish the relative contribution of the RA-associated subtypes of DR4 (Dw4, Dw14, and Dw15). There was an excess of DR4 homozygotes, particularly Dw4/Dw14 compound heterozygotes (relative risk [RR] 49). The risk associated with Dw4 depended on the other allele...
Topics
- Alleles
- Arthritis, Rheumatoid
- Disease Susceptibility
- Gene Frequency
- Genes, MHC Class II
- HLA-DR1 Antigen
- HLA-DR4 Antigen
- Heterozygote
- Humans