Article
Rheumatoid arthritis may be primarily associated with HLA-DR4 molecules sharing a particular sequence at residues 67-74.
Tissue antigens - 1 Nov 1990
Rønningen K S, Spurkland A, Egeland T, Iwe T, Munthe E, Vartdal F, Thorsby E
Abstract excerpt
Genomic typing of in vitro amplified DNA with sequence-specific oligonucleotide (SSO) probes was performed for DRB1, DQA1, DQB1, DPA1 and DPB1 alleles in 54 random Norwegian rheumatoid arthritis (RA) patients and 181 healthy controls. DRB1 alleles encoding the serological specificity DR4 were found in 80% of the patients, compared to 34% of the controls (relative risk = 7.9, p less than 0.0001). All DR4-positive...
Topics
- Alleles
- Arthritis, Rheumatoid
- Base Sequence
- DNA Probes
- HLA-DR4 Antigen
- Humans
- Molecular Sequence Data
- Norway