Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic changes in methotrexate-resistant mosquito cells.

Archives of insect biochemistry and physiology - 1 Jan 1990

Shotkoski F A, Fallon A M

Abstract excerpt

A stepwise selection procedure was used to obtain from Mtx-5011 Aedes albopictus cells, variants with increased resistance to methotrexate (mtx). On the basis of growth, the Mtx-5011 derivatives were 270- to 3,000-fold more resistant to mtx than wild-type mosquito cells. Properties associated wit...

Topics

Aedes
Animals
Blotting, Southern
Cell Line
DNA
Drug Resistance
Gene Amplification
Genetic Variation
Karyotyping
Larva
Methotrexate
Ploidies
Poly A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Biosynthesis

Proteins

RNA

RNA, Messenger

Tetrahydrofolate Dehydrogenase

Source

Identifiers

PMID: 1724612
DOI: 10.1002/arch.940150203

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1724612-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic changes in methotrexate-resistant mosquito cells.PMID 1724612Read ↗

Isolation and characterization of a dihydrofolate reductase gene mutation in methotrexate-resistant Drosophila cells.Semantic proximity Read ↗

Characterisation of methotrexate-resistant clones.Semantic proximity Read ↗

P-glycoprotein overexpression in methotrexate-resistant Leishmania tropica.Semantic proximity Read ↗

Dihydrofolate Reductase and Thymidylate Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene RegulationSemantic proximity Read ↗

Drosophila dihydrofolate reductase mutations confer antifolate resistance to mammalian cells.Semantic proximity Read ↗

A comparison of the propensity for gene amplification between near-tetraploid and near-diploid V79 clones resistant to 150 nM methotrexate.Semantic proximity Read ↗

Resistance to methotrexate due to AcrAB-dependent export from Escherichia coli.Semantic proximity Read ↗

Molecular mechanisms of resistance to antifolates, a review.Semantic proximity Read ↗

Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae.Semantic proximity Read ↗

Isolation and characterization of a mutant dihydrofolate reductase-thymidylate synthase from methotrexate-resistant Leishmania cells.Semantic proximity Read ↗

A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells.Semantic proximity Read ↗

Identification and characterization of a mutation in the dihydrofolate reductase gene from the methotrexate-resistant Chinese hamster ovary cell line Pro-3 MtxRIII.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.