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Article

Genetic changes in methotrexate-resistant mosquito cells.

Archives of insect biochemistry and physiology - 1 Jan 1990

Shotkoski F A, Fallon A M

Abstract excerpt

A stepwise selection procedure was used to obtain from Mtx-5011 Aedes albopictus cells, variants with increased resistance to methotrexate (mtx). On the basis of growth, the Mtx-5011 derivatives were 270- to 3,000-fold more resistant to mtx than wild-type mosquito cells. Properties associated with mtx resistance in these cells were consistent with amplification of the dihydrofolate reductase (DHFR) gene. The...

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PMID: 1724612
DOI: 10.1002/arch.940150203

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DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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