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Article

Drosophila dihydrofolate reductase mutations confer antifolate resistance to mammalian cells.

European journal of pharmacology - 4 Jan 2006

Affleck Joslynn G, Al-Batayneh Khalid M, Neumann Katerina, Cole Susan P C, Walker Virginia K

Abstract excerpt

Antifolates, such as methotrexate, are used to inhibit dihydrofolate reductase (DHFR), an enzyme essential for the biosynthesis of thymidylate, purines, and several amino acids. DHFR sequences corresponding to mutations found in a methotrexate resistant Drosophila S3 cell line (L30Q), a methotrexate resistant fly population (K31P, Q134K), as well as predicted in silico (L22R) were expressed in Chinese Hamster...

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Source

Identifiers

PMID: 16325803
DOI: 10.1016/j.ejphar.2005.10.054

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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