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Article

A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells.

Cancer research - 1 Jun 1991

Sharma R C, Assaraf Y G, Schimke R T

Abstract excerpt

Trimetrexate, a lipid-soluble analogue of methotrexate, appears to enter mammalian cells by passive diffusion, thus circumventing the methotrexate transport system which is frequently a subject for alterations leading to methotrexate resistance. Using a single-step selection protocol with trimetrexate, we have isolated 45 clonal variants and found the majority of them to be selectively resistant to lipophilic...

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PMID: 1674447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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