A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells.

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Article

A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells.

Cancer research - 1 Jun 1991

Sharma R C, Assaraf Y G, Schimke R T

Abstract excerpt

Trimetrexate, a lipid-soluble analogue of methotrexate, appears to enter mammalian cells by passive diffusion, thus circumventing the methotrexate transport system which is frequently a subject for alterations leading to methotrexate resistance. Using a single-step selection protocol with trimetr...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Binding, Competitive
Cell Line
Cricetinae
Drug Resistance
Folic Acid Antagonists
Gene Amplification
Membrane Glycoproteins
Methotrexate
Phenotype
Pyrimidines
Quinazolines
RNA, Messenger
Tetrahydrofolate Dehydrogenase
Trimetrexate
Verapamil

Source

Open in PubMed

Identifiers

PMID: 1674447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1674447-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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