Characterisation of methotrexate-resistant clones.

doi:10.1016/0165-1161(93)90016-s

Back to search

Article

Characterisation of methotrexate-resistant clones.

Mutation research - 1 Feb 1993

Roy M, Sengupta S, Ghosh R, Bhattacharyya N P, Dey S K, Bhattacharjee S B

Abstract excerpt

Three methotrexate (MTX)-resistant clones M1, M2 and M3 have been isolated from Chinese hamster V79 cells and characterised for aneuploidy, chromosomal aberrations, sister-chromatid exchange (SCE) mutation and transfection. Amplification of the dihydrofolate reductase (DHFR) gene in these clones...

Topics

Animals
Cell Division
Cells, Cultured
Chromosome Aberrations
Cricetinae
Cricetulus
Drug Resistance
Male
Methotrexate
Mutation
Sister Chromatid Exchange
Tetrahydrofolate Dehydrogenase
Transfection

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.