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Article

Characterisation of methotrexate-resistant clones.

Mutation research - 1 Feb 1993

Roy M, Sengupta S, Ghosh R, Bhattacharyya N P, Dey S K, Bhattacharjee S B

Abstract excerpt

Three methotrexate (MTX)-resistant clones M1, M2 and M3 have been isolated from Chinese hamster V79 cells and characterised for aneuploidy, chromosomal aberrations, sister-chromatid exchange (SCE) mutation and transfection. Amplification of the dihydrofolate reductase (DHFR) gene in these clones has been established from (a) direct measurement of DHFR activity, (b) existence of double minute chromosomes and (c)...

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Source

Identifiers

PMID: 7678914
DOI: 10.1016/0165-1161(93)90016-s

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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