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Article

Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation.

The Journal of cell biology - 29 Jan 2007

Mandal Atin K, Lee Paul, Chen Jennifer A, Nillegoda Nadinath, Heller Alana, DiStasio Susan, Oen Handy, Victor Jacob, Nair Devi M, Brodsky Jeffrey L, Caplan Avrom J

Abstract excerpt

Cdc37 is a molecular chaperone that functions with Hsp90 to promote protein kinase folding. Analysis of 65 Saccharomyces cerevisiae protein kinases ( approximately 50% of the kinome) in a cdc37 mutant strain showed that 51 had decreased abundance compared with levels in the wild-type strain. Several lipid kinases also accumulated in reduced amounts in the cdc37 mutant strain. Results from our pulse-labeling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17242065
DOI: 10.1083/jcb.200604106
PMCID: PMC1857360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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