Article
A positive feedback loop between protein kinase CKII and Cdc37 promotes the activity of multiple protein kinases.
The Journal of biological chemistry - 31 Jan 2003
Bandhakavi Sricharan, McCann Richard O, Hanna David E, Glover Claiborne V C
Abstract excerpt
We report here the identification of CDC37, which encodes a putative Hsp90 co-chaperone, as a multicopy suppressor of a temperature-sensitive allele (cka2-13(ts)) of the CKA2 gene encoding the alpha' catalytic subunit of protein kinase CKII. Unlike wild-type cells, cka2-13 cells were sensitive to the Hsp90-specific inhibitor geldanamycin, and this sensitivity was suppressed by overexpression of either Hsp90 or...
Topics
- Amino Acid Sequence
- Casein Kinase II
- Cell Cycle Proteins
- Drosophila Proteins
- Feedback
- Genotype
- HSP90 Heat-Shock Proteins
- Kinetics
- Molecular Chaperones
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phosphorylation
- Protein Kinases