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Article

A positive feedback loop between protein kinase CKII and Cdc37 promotes the activity of multiple protein kinases.

The Journal of biological chemistry - 31 Jan 2003

Bandhakavi Sricharan, McCann Richard O, Hanna David E, Glover Claiborne V C

Abstract excerpt

We report here the identification of CDC37, which encodes a putative Hsp90 co-chaperone, as a multicopy suppressor of a temperature-sensitive allele (cka2-13(ts)) of the CKA2 gene encoding the alpha' catalytic subunit of protein kinase CKII. Unlike wild-type cells, cka2-13 cells were sensitive to the Hsp90-specific inhibitor geldanamycin, and this sensitivity was suppressed by overexpression of either Hsp90 or...

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Identifiers

PMID: 12435747
DOI: 10.1074/jbc.M206662200

Genes

CDC37

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A positive feedback loop between protein kinase CKII and Cdc37 promotes the activity of multiple protein kinases.PMID 12435747Read ↗

Genetic interactions among ZDS1,2, CDC37, and protein kinase CK2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Dissecting the Cdc37 cochaperone code: Functional roles in chaperone-mediated stress adaptation.Semantic proximity Read ↗

Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.Semantic proximity Read ↗

Alteration of the protein kinase binding domain enhances function of the Saccharomyces cerevisiae molecular chaperone Cdc37.Semantic proximity Read ↗

Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.Semantic proximity Read ↗

Genome-wide expression screens indicate a global role for protein kinase CK2 in chromatin remodeling.Semantic proximity Read ↗

Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation.Semantic proximity Read ↗

The Ring-H2 finger motif of CKBBP1/SAG is necessary for interaction with protein kinase CKII and optimal cell proliferation.Semantic proximity Read ↗

Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1).Semantic proximity Read ↗

Differential phosphorylation of a regulatory subunit of protein kinase CK2 by target of rapamycin complex 1 signaling and the Cdc-like kinase Kns1.Semantic proximity Read ↗

Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins.Semantic proximity Read ↗

The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability.Semantic proximity Read ↗

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