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Article

Comparative analysis of the impact of Heat shock protein 90 kDa or Cdc37 mutation on the yeast proteome.

Cell stress & chaperones - 1 May 2026

Rios Erick I, Johnson Jill L

Abstract excerpt

Hsp90 is an abundant and essential molecular chaperone that is required for the folding and/or activity of up to 15%-20% of all yeast proteins. Hsp90 and its cochaperone Cdc37 are of interest due to their cooperative role in chaperoning oncogenic protein kinases. We previously grouped mutants in Saccharomyces cerevisiae Hsp90 into different categories based on the step of the adenosine triphosphate-dependent...

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Identifiers

PMID: 41794062
DOI: 10.1016/j.cstres.2026.100164
PMCID: PMC13015669

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