Dissecting the Cdc37 cochaperone code: Functional roles in chaperone-mediated stress adaptation.

Abstract excerpt

Cell division cycle 37 (Cdc37) is a kinase-specific cochaperone that scaffolds protein kinase clients to the heat shock 90 (Hsp90) chaperone system. Although phosphorylation at residues S14 and S17 is known to regulate Cdc37 function, the broader role of phosphorylation across the protein remains unclear. To systematically investigate this, we created a "Cdc37 code collection," a set of 46 yeast strains...

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