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Article

Ydj1 protects nascent protein kinases from degradation and controls the rate of their maturation.

Molecular and cellular biology - 1 Jul 2008

Mandal Atin K, Nillegoda Nadinath B, Chen Jennifer A, Caplan Avrom J

Abstract excerpt

Ydj1 is a Saccharomyces cerevisiae Hsp40 molecular chaperone that functions with Hsp70 to promote polypeptide folding. We identified Ydj1 as being important for maintaining steady-state levels of protein kinases after screening several chaperones and cochaperones in gene deletion mutant strains. Pulse-chase analyses revealed that a portion of Tpk2 kinase was degraded shortly after synthesis in a ydj1Delta mutant,...

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Share to CDC28 Protein Kinase, S cerevisiae
Share to Cyclic AMP-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Stability

Share to HSP40 Heat-Shock Proteins

Share to HSP90 Heat-Shock Proteins

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Share to Protein Processing, Post-Translational

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Source

Open in PubMed Open full text

Identifiers

PMID: 18443039
DOI: 10.1128/MCB.00543-08
PMCID: PMC2447146

Genes

CDC37

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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