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Article

The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability.

The Journal of cell biology - 23 Dec 2002

Lee Paul, Rao Jie, Fliss Albert, Yang Emy, Garrett Stephen, Caplan Avrom J

Abstract excerpt

Cdc37 is a molecular chaperone required for folding of protein kinases. It functions in association with Hsp90, although little is known of its mechanism of action or where it fits into a folding pathway involving other Hsp90 cochaperones. Using a genetic approach with Saccharomyces cerevisiae, we show that CDC37 overexpression suppressed a defect in v-Src folding in yeast deleted for STI1, which recruits Hsp90...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12499358
DOI: 10.1083/jcb.200210121
PMCID: PMC2173992

Genes

CDC37

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability.PMID 12499358Read ↗

Cdc37 is a molecular chaperone with specific functions in signal transduction.Semantic proximity Read ↗

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Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation.Semantic proximity Read ↗

Physical interaction of Cdc28 with Cdc37 in Saccharomyces cerevisiae.Semantic proximity Read ↗

The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest.Semantic proximity Read ↗

Alteration of the protein kinase binding domain enhances function of the Saccharomyces cerevisiae molecular chaperone Cdc37.Semantic proximity Read ↗

Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.Semantic proximity Read ↗

CDC37 is required for p60v-src activity in yeast.Semantic proximity Read ↗

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Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase.Semantic proximity Read ↗

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