Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cdc37 promotes the stability of protein kinases Cdc28 and Cak1.

Molecular and cellular biology - 1 Feb 2000

Farrell A, Morgan D O

Abstract excerpt

In the budding yeast Saccharomyces cerevisiae, Cdc37 is required for the productive formation of Cdc28-cyclin complexes. The cdc37-1 mutant arrests at Start with low levels of Cdc28 protein, which is predominantly unphosphorylated at Thr169, fails to bind cyclin, and has little protein kinase activity. We show here that Cdc28 and not cyclin is specifically defective in the cdc37-1 mutant and that Cdc37 likely...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CDC28 Protein Kinase, S cerevisiae
Share to Cell Cycle Proteins
Share to Cyclin-Dependent Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Stability

Share to Molecular Chaperones

Share to Mutagenesis

Share to Phosphothreonine

Share to Protein Biosynthesis

Source

Open in PubMed Open full text

Identifiers

PMID: 10629030
DOI: 10.1128/MCB.20.3.749-754.2000
PMCID: PMC85190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cdc37 promotes the stability of protein kinases Cdc28 and Cak1.PMID 10629030Read ↗

Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation.Semantic proximity Read ↗

A phosphorylation-independent role for the yeast cyclin-dependent kinase activating kinase Cak1.Semantic proximity Read ↗

Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1).Semantic proximity Read ↗

Physical interaction of Cdc28 with Cdc37 in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability.Semantic proximity Read ↗

Cak1 is required for Kin28 phosphorylation and activation in vivo.Semantic proximity Read ↗

Activity of Cdc2 and its interaction with the cyclin Cdc13 depend on the molecular chaperone Cdc37 in Schizosaccharomyces pombe.Semantic proximity Read ↗

Activating phosphorylation of the Saccharomyces cerevisiae cyclin-dependent kinase, cdc28p, precedes cyclin binding.Semantic proximity Read ↗

The Cak1p protein kinase is required at G1/S and G2/M in the budding yeast cell cycle.Semantic proximity Read ↗

Alteration of the protein kinase binding domain enhances function of the Saccharomyces cerevisiae molecular chaperone Cdc37.Semantic proximity Read ↗

A Whi7-anchored loop controls the G1 Cdk-cyclin complex at start.Semantic proximity Read ↗

Loss of a protein phosphatase 2A regulatory subunit (Cdc55p) elicits improper regulation of Swe1p degradation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.