Cdc37 is a molecular chaperone with specific functions in signal transduction.

doi:10.1101/gad.11.14.1775

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Article

Cdc37 is a molecular chaperone with specific functions in signal transduction.

Genes & development - 15 Jul 1997

Kimura Y, Rutherford S L, Miyata Y, Yahara I, Freeman B C, Yue L, Morimoto R I, Lindquist S

Abstract excerpt

Cdc37 is required for cyclin-dependent kinase activation and is genetically linked with the activity of several other kinases, including oncogenic v-Src, casein kinase II, MPS-1 kinase, and sevenless. Strikingly, many pathways involving Cdc37 also involve the protein chaperone Hsp90. The identifi...

Topics

Cell Cycle Proteins
Drosophila Proteins
Enzyme Activation
Enzyme Stability
HSP90 Heat-Shock Proteins
Molecular Chaperones
Phenotype
Protein Denaturation
Signal Transduction
Substrate Specificity
src-Family Kinases

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