Article
Cdc37 is a molecular chaperone with specific functions in signal transduction.
Genes & development - 15 Jul 1997
Kimura Y, Rutherford S L, Miyata Y, Yahara I, Freeman B C, Yue L, Morimoto R I, Lindquist S
Abstract excerpt
Cdc37 is required for cyclin-dependent kinase activation and is genetically linked with the activity of several other kinases, including oncogenic v-Src, casein kinase II, MPS-1 kinase, and sevenless. Strikingly, many pathways involving Cdc37 also involve the protein chaperone Hsp90. The identification of Cdc37 as the 50-kD protein in several Hsp90-kinase complexes, together with other data, led to the recent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.