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Article

Alpha interferon inhibits hepatitis C virus replication in primary human hepatocytes infected in vitro.

Journal of virology - 1 Aug 2002

Castet Valérie, Fournier Chantal, Soulier Alexandre, Brillet Rozenn, Coste Joliette, Larrey Dominique, Dhumeaux Daniel, Maurel Patrick, Pawlotsky Jean-Michel

Abstract excerpt

Chronic hepatitis C is a common cause of liver disease, the complications of which include cirrhosis and hepatocellular carcinoma. Treatment of chronic hepatitis C is based on the use of alpha interferon (IFN-alpha). Recently, indirect evidence based on mathematical modeling of hepatitis C virus (HCV) dynamics during human IFN-alpha therapy suggested that the major initial effect of IFN-alpha is to block HCV...

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Share to Antiviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

Share to Hepatocytes

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Share to Interferon alpha-2

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Source

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Identifiers

PMID: 12134024
DOI: 10.1128/jvi.76.16.8189-8199.2002
PMCID: PMC155162

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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