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Article

Hepatitis c virus genotype 4 replication in the hepatocellular carcinoma cell line HepG2/C3A.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association - 1 Jan 2000

Shier Medhat K, El-Wetidy Mohammad S, Ali Hebatallah H, Al-Qattan Mohammad M

Abstract excerpt

BACKGROUND/AIMS: The lack of a reliable cell culture system allowing persistent in vitro hepatitis C virus (HCV) propagation is still restraining the search for novel antiviral strategies. HepG2 cells transfection with HCV allows for viral replication. However, the replication is weak presumably because of HepG2 lack of miRNA-122, which is essential for viral replication. Other agents such as polyethylene glycol...

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Identifiers

PMID: 27184644
DOI: 10.4103/1319-3767.182461
PMCID: PMC4898095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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