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Azathioprine Inhibits Hepatitis A Virus Replication In Vitro.

Pathogens (Basel, Switzerland) - 26 Feb 2026

Kanda Tatsuo, Sasaki-Tanaka Reina, Abe Hiroyuki, Yokoo Takeshi, Sakamaki Akira, Hayashi Kazunao, Kamimura Hiroteru, Kamimura Kenya, Masuzaki Ryota, Kogure Hirofumi, Okamoto Hiroaki, Terai Shuji

Abstract excerpt

Hepatitis A virus (HAV) infection can occasionally cause acute severe hepatitis. Patients with this disease sometimes need to undergo liver transplantation with immunosuppressants. Although rare, breakthrough HAV infections, despite vaccination, appear to be more common among immunocompromised populations. The effect of immunosuppressants on HAV replication is unclear. In this study, we examined the effects of...

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Identifiers

PMID: 41901703
DOI: 10.3390/pathogens15030249
PMCID: PMC13029016

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