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Article

Common polymorphisms in 5-lipoxygenase and 12-lipoxygenase genes and the risk of incident, sporadic colorectal adenoma.

Cancer - 1 Mar 2007

Gong Zhihong, Hebert James R, Bostick Roberd M, Deng Zonglin, Hurley Thomas G, Dixon Dan A, Nitcheva Daniela, Xie Dawen

Abstract excerpt

BACKGROUND: Lipoxygenases (LOX) are major enzymes that metabolize arachidonic acid to hydroxyl-eicosatetraenoic acids and leukotrienes, which have been implicated in inflammation and colorectal cancer risk. Polymorphisms in LOX genes may influence their function and/or expression and, thus, may modify the risk for colorectal adenoma. The authors investigated the associations of 3 polymorphisms (2 in 5-LOX, -1708...

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Source

Identifiers

PMID: 17236225
DOI: 10.1002/cncr.22469

Genes

LOX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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