Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Non-synonymous polymorphism (Gln261Arg) of 12-lipoxygenase in colorectal and thyroid cancers.

Familial cancer - 1 Dec 2012

Prasad Vidudala V T S, Padma Kolli

Abstract excerpt

12-lipoxygenase (12-LOX) pathway which produces 12-HETE and hepoxiline HXA3 and HXB3, and induces production of reactive oxygen species and inflammation is increasingly being implicated in variety of cancers, including those of colorectal and thyroid cancers. Hence, we examined whether the functional polymorphism of 12-LOX (mRNA A835G; Protein Gln261Arg) has any association with human colorectal and thyroid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Arachidonate 12-Lipoxygenase
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to LOX gene

Share to Polymorphism, Single Nucleotide

Share to Prognosis

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 22864639
DOI: 10.1007/s10689-012-9559-x

Genes

LOX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-synonymous polymorphism (Gln261Arg) of 12-lipoxygenase in colorectal and thyroid cancers.PMID 22864639Read ↗

[Association of genetic variant in 12-lipoxygenase and risk of hepatic carcinoma].Semantic proximity Read ↗

Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer.Semantic proximity Read ↗

PER1 rs3027188 Polymorphism and its Association with the Risk of Colorectal Cancer in the Japanese Population.Semantic proximity Read ↗

Determination of autophagy gene ATG16L1 polymorphism in human colorectal cancer.Semantic proximity Read ↗

Common polymorphisms in 5-lipoxygenase and 12-lipoxygenase genes and the risk of incident, sporadic colorectal adenoma.Semantic proximity Read ↗

Lysyl oxidase rs1800449 polymorphism and cancer risk among Asians: evidence from a meta-analysis and a case-control study of colorectal cancer.Semantic proximity Read ↗

A critical analysis of the relationship between aldehyde dehydrogenases-2 Glu487Lys polymorphism and colorectal cancer susceptibility.Semantic proximity Read ↗

Investigating the role of the Pon1-rs854560 (L55M) SNP in colorectal Cancer susceptibility.Semantic proximity Read ↗

Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.Semantic proximity Read ↗

The Analysis of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Polish Patients with Colorectal Cancer.Semantic proximity Read ↗

Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis.Semantic proximity Read ↗

Role of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Prevention, Diagnosis, and Treatment of Gastrointestinal Cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.