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Article

Genetic variation in prostaglandin synthesis and related pathways, NSAID use and colorectal cancer risk in the Colon Cancer Family Registry.

Carcinogenesis - 1 Sept 2014

Resler Alexa J, Makar Karen W, Heath Laura, Whitton John, Potter John D, Poole Elizabeth M, Habermann Nina, Scherer Dominique, Duggan David, Wang Hansong, Lindor Noralane M, Passarelli Michael N, Baron John A, Newcomb Polly A, Le Marchand Loic, Ulrich Cornelia M

Abstract excerpt

Although use of non-steroidal anti-inflammatory drugs (NSAIDs) generally decreases colorectal cancer (CRC) risk, inherited genetic variation in inflammatory pathways may alter their potential as preventive agents. We investigated whether variation in prostaglandin synthesis and related pathways influences CRC risk in the Colon Cancer Family Registry by examining associations between 192 single nucleotide...

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Share to Anti-Inflammatory Agents, Non-Steroidal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24908683
DOI: 10.1093/carcin/bgu119
PMCID: PMC4146420

Genes

ALOX12
PTGER2

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