Article
Polymorphisms in Cyclooxygenase, Lipoxygenase, and TP53 Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial.
Cancer prevention research (Philadelphia, Pa.) - 1 Nov 2023
Davies John R, Mell Tracey, Fuller Harriett, Harland Mark, Saleh Rasha N M, Race Amanda D, Rees Colin J, Brown Louise C, Loadman Paul M, Downing Amy, Minihane Anne Marie, Williams Elizabeth A, Hull Mark A
Abstract excerpt
Aspirin and eicosapentaenoic acid (EPA) reduce colorectal adenomatous polyp risk and affect synthesis of oxylipins including prostaglandin E2. We investigated whether 35 SNPs in oxylipin metabolism genes such as cyclooxygenase (PTGS) and lipoxygenase (ALOX), as well as 7 SNPs already associated with colorectal cancer risk reduction by aspirin (e.g., TP53; rs104522), modified the effects of aspirin and EPA on...
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