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Article

Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.

Genes, chromosomes & cancer - 1 May 2013

Kleinstein Sarah E, Heath Laura, Makar Karen W, Poole Elizabeth M, Seufert Brenna L, Slattery Martha L, Xiao Liren, Duggan David J, Hsu Li, Curtin Karen, Koepl Lisel, Muehling Jill, Taverna Darin, Caan Bette J, Carlson Christopher S, Potter John D, Ulrich Cornelia M

Abstract excerpt

Arachidonate lipoxygenase (ALOX) enzymes metabolize arachidonic acid to generate potent inflammatory mediators and play an important role in inflammation-associated diseases. We investigated associations between colorectal cancer risk and polymorphisms in ALOX5, FLAP, ALOX12, and ALOX15, and their interactions with nonsteroidal anti-inflammatory drug (NSAID) use. We genotyped fifty tagSNPs, one candidate SNP, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23404351
DOI: 10.1002/gcc.22042
PMCID: PMC3698944

Genes

ALOX15
ALOX12
ALOX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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