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Article

Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer.

Familial cancer - 1 Dec 2013

Li Shuying, Zhao Xiaojuan, Wu Zhiwei, Li Ye, Zhu Lin, Cui Binbin, Dong Xinshu, Tian Suli, Hu Fulan, Zhao Yashuang

Abstract excerpt

Cyclooxygenase-2 (COX-2), 12-lipoxygenase (12-LOX) and phospholipaseA2 (PLA2) played important roles in the modulation of apoptosis, angiogenesis, carcinogenesis and invasion of colorectal cancer (CRC). The polymorphisms in COX-2, 12-LOX and PLA2 may affect their roles. Therefore, we investigated if COX-2 -1195G > A, 12-LOX 261Arg > Gln and PLA2 c.349 + 191A > G polymorphisms were associated with risk and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23715757
DOI: 10.1007/s10689-013-9659-2

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LOX

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