Article
Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population.
Neuroreport - 12 Feb 2007
Funayama Manabu, Li Yuanzhe, Tomiyama Hiroyuki, Yoshino Hiroyo, Imamichi Yoko, Yamamoto Mitsutoshi, Murata Miho, Toda Tatsushi, Mizuno Yoshikuni, Hattori Nobutaka
Abstract excerpt
To assess the effect of genetic factors on sporadic Parkinson disease, we performed a case-control study of a variant (G2385R) in Leucine-Rich Repeat kinase 2 among the Japanese population. The G2385R (c.7153G>A) variant was reported as a risk factor for sporadic Parkinson disease in the Chinese population from Taiwan and Singapore. Genotyping was conducted in 448 Parkinson disease patients and 457 healthy...
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