Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice.

Matrix biology : journal of the International Society for Matrix Biology - 1 May 2007

Akiyama Haruhiko, Stadler H Scott, Martin James F, Ishii Takahiro M, Beachy Philip A, Nakamura Takashi, de Crombrugghe Benoit

Abstract excerpt

Our previous studies have demonstrated the essential roles of the transcription factor Sox9 in the commitment of mesenchymal cells to a chondrogenic cell lineage and in overt chondrogenesis during limb bud development. However, it remains unknown if Sox9 induces chondrogenesis in mesenchyme ectopically in vivo as a master regulator of chondrogenesis. In this study, we first generated mutant mice in which Sox9 was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to High Mobility Group Proteins

Share to Limb Buds

Share to Mesoderm

Share to Polydactyly

Share to SOX9 Transcription Factor

Source

Identifiers

PMID: 17222543
DOI: 10.1016/j.matbio.2006.12.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice.PMID 17222543Read ↗

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.Semantic proximity Read ↗

Impairment of Sox9 expression in limb buds of rats homozygous for hypodactyly mutation.Semantic proximity Read ↗

Dynamics of BMP signaling in limb bud mesenchyme and polydactyly.Semantic proximity Read ↗

Dominance of SOX9 function over RUNX2 during skeletogenesisSemantic proximity Read ↗

Sox9 is required for cartilage formation.Semantic proximity Read ↗

Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation.Semantic proximity Read ↗

The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements.Semantic proximity Read ↗

Altered Hox expression and increased cell death distinguish Hypodactyly from Hoxa13 null mice.Semantic proximity Read ↗

Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth.Semantic proximity Read ↗

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization.Semantic proximity Read ↗

Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton.Semantic proximity Read ↗

The postnatal role of Sox9 in cartilage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.