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Article

Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton.

Developmental biology - 15 Jun 2007

Yu Ling, Liu Hongbing, Yan Mingquan, Yang Jing, Long Fanxin, Muneoka Ken, Chen YiPing

Abstract excerpt

Mutations in the short stature homeobox gene SHOX lead to growth retardation associated with Turner, Leri-Weill dyschondrosteosis, and Langer mesomelic dysplasia syndromes, which marked the shortening of the forearms and lower legs. We report here that in contrast to the SHOX mutations in humans,...

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Source

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Identifiers

PMID: 17481601
DOI: 10.1016/j.ydbio.2007.03.518
PMCID: PMC2062576

Genes

SHOX
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17481601-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton.PMID 17481601Read ↗

A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development.Semantic proximity Read ↗

Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb.Semantic proximity Read ↗

The short stature homeobox gene SHOX is involved in skeletal abnormalities in Turner syndrome.Semantic proximity Read ↗

<i>Shox2</i>-deficient mice exhibit a rare type of incomplete clefting of the secondary palateSemantic proximity Read ↗

NPPB and ACAN, two novel SHOX2 transcription targets implicated in skeletal development.Semantic proximity Read ↗

SHOX at a glance: from gene to protein.Semantic proximity Read ↗

FGFR3 is a target of the homeobox transcription factor SHOX in limb development.Semantic proximity Read ↗

<i>SHOX</i> haploinsufficiency and overdosage: impact of gonadal function statusSemantic proximity Read ↗

Overexpression of Shox2 leads to congenital dysplasia of the temporomandibular joint in mice.Semantic proximity Read ↗

Short stature and dysmorphology associated with defects in the SHOX gene.Semantic proximity Read ↗

SHOX in short stature syndromes.Semantic proximity Read ↗

Transcriptional regulators of chondrocyte hypertrophySemantic proximity Read ↗

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