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Article

The postnatal role of Sox9 in cartilage.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2012

Henry Stephen P, Liang Shoudan, Akdemir Kadir C, de Crombrugghe Benoit

Abstract excerpt

Sox9 is an essential transcription factor for the differentiation of the chondrocytic lineage during embryonic development. To test whether Sox9 continues to play a critical role in cartilaginous tissues in the adult mice, we used an inducible, genetic strategy to disrupt the Sox9 gene postnatally in these tissues. The postnatal inactivation of Sox9 led to stunted growth characterized by decreased proliferation,...

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Topics

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Share to Cartilage, Articular
Share to Collagen Type II

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Growth Plate

Share to Intervertebral Disc

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Source

Open in PubMed Open full text

Identifiers

PMID: 22777888
DOI: 10.1002/jbmr.1696
PMCID: PMC3502666

Genes

IVD
ADAMTS5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The postnatal role of Sox9 in cartilage.PMID 22777888Read ↗

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