Article
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.
Genes & development - 1 Nov 2002
Akiyama Haruhiko, Chaboissier Marie-Christine, Martin James F, Schedl Andreas, de Crombrugghe Benoit
Abstract excerpt
To examine whether the transcription factor Sox9 has an essential role during the sequential steps of chondrocyte differentiation, we have used the Cre/loxP recombination system to generate mouse embryos in which either Sox9 is missing from undifferentiated mesenchymal cells of limb buds or the Sox9 gene is inactivated after chondrogenic mesenchymal condensations. Inactivation of Sox9 in limb buds before...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Chondrocytes
- DNA-Binding Proteins
- Gene Expression Regulation, Developmental
- High Mobility Group Proteins
- Mice
- Mutation
- Nuclear Proteins
- SOX9 Transcription Factor
- SOXD Transcription Factors