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Article

Sox9 is required for cartilage formation.

Nature genetics - 1 May 1999

Bi W, Deng J M, Zhang Z, Behringer R R, de Crombrugghe B

Abstract excerpt

Chondrogenesis results in the formation of cartilages, initial skeletal elements that can serve as templates for endochondral bone formation. Cartilage formation begins with the condensation of mesenchyme cells followed by their differentiation into chondrocytes. Although much is known about the terminal differentiation products that are expressed by chondrocytes, little is known about the factors that specify...

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Source

Identifiers

PMID: 10319868
DOI: 10.1038/8792

Genes

SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sox9 is required for cartilage formation.PMID 10319868Read ↗

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.Semantic proximity Read ↗

SOX9 and the many facets of its regulation in the chondrocyte lineageSemantic proximity Read ↗

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization.Semantic proximity Read ↗

The postnatal role of Sox9 in cartilage.Semantic proximity Read ↗

Dominance of SOX9 function over RUNX2 during skeletogenesisSemantic proximity Read ↗

<i>Sox9</i> in Testis DeterminationSemantic proximity Read ↗

SOX9 in cartilage development and diseaseSemantic proximity Read ↗

Variants in the SOX9 transactivation middle domain induce axial skeleton dysplasia and scoliosisSemantic proximity Read ↗

Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes.Semantic proximity Read ↗

Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasiaSemantic proximity Read ↗

Interactions between Sox9 and beta-catenin control chondrocyte differentiation.Semantic proximity Read ↗

SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling.Semantic proximity Read ↗

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