Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth.

doi:10.1242/dev.124.3.627

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Article

Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth.

Development (Cambridge, England) - 1 Feb 1997

Goff D J, Tabin C J

Abstract excerpt

Hox genes are important regulators of limb pattern in vertebrate development. Misexpression of Hox genes in chicks using retroviral vectors provides an opportunity to analyze gain-of-function phenotypes and to assess their modes of action. Here we report the misexpression phenotype for Hoxd-13 an...

Topics

Animals
Bone and Bones
Cell Division
Chick Embryo
Extremities
Gene Expression Regulation, Developmental
Genes, Homeobox
Phenotype

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