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Article

Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer.

Molecular carcinogenesis - 1 Sept 2015

Shen Rong, Liu Hongliang, Wen Juyi, Liu Zhensheng, Wang Li-E, Wang Qiming, Tan Dongfeng, Ajani Jaffer A, Wei Qingyi

Abstract excerpt

Thymidylate synthase (TYMS) plays a crucial role in folate metabolism as well as DNA synthesis and repair. We hypothesized that functional polymorphisms in the 3' UTR of TYMS are associated with gastric cancer risk and survival. In the present study, we tested our hypothesis by genotyping three potentially functional (at miRNA binding sites) TYMS SNPs (rs16430 6bp del/ins, rs2790 A>G and rs1059394 C>T) in 379...

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Identifiers

PMID: 24756984
DOI: 10.1002/mc.22160

Genes

TYMS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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