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Thymidylate synthase gene polymorphisms as important contributors affecting hepatocellular carcinoma prognosis.

Clinics and research in hepatology and gastroenterology - 1 Jun 2017

Wang X, Sun X, Du X, Zhou F, Yang F, Xing J, Dong G, Guo X

Abstract excerpt

BACKGROUND: Thymidylate synthase (TYMS), a key rate-limiting enzyme in the folate metabolism, plays essential roles in the development of several malignancies including hepatocellular carcinoma (HCC). Nonetheless, the association of the single nucleotide polymorphisms (SNPs) in TYMS gene with the prognosis of Chinese HCC patients remains unknown. METHODS: A total of 492 HCC patients who underwent surgery...

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PMID: 28043790
DOI: 10.1016/j.clinre.2016.10.012

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TYMS

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