Article
Prevalence of thymidylate synthase gene 5'-untranslated region variants in an Argentinean sample.
Genetics and molecular research : GMR - 23 Jan 2017
Vázquez C, Orlova M, Scibona P, Díaz Arce H, Pallotta M G, Belloso W H
Abstract excerpt
Thymidylate synthase (TYMS) is a key enzyme in nucleotide synthesis and therefore, an important target of many chemotherapeutic agents. Expression of TYMS mRNA is thought to be modulated by a 28-bp tandem repeat polymorphism within its 5'-untranslated region, raising the question of this variant's utility in predicting the efficacy and toxicity of cancer treatment regimens. The aim of the present research was to...
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