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Article

A novel G/C single-nucleotide polymorphism in the double 28-bp repeat thymidylate synthase allele.

The pharmacogenomics journal - 1 Jan 2000

Gusella M, Bolzonella C, Crepaldi G, Ferrazzi E, Padrini R

Abstract excerpt

Thymidylate synthase (TYMS) is the main molecular target for fluoropyrimidine anticancer drugs, and its expression has been correlated with the number of repeats of a 28-bp sequence in the 5'-untranslated region of the TYMS gene and with the presence of a G --> C single-nucleotide polymorphism in the second repeat of 3R alleles. Based on this double polymorphism, three main TYMS alleles have so far been...

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Source

Identifiers

PMID: 16868573
DOI: 10.1038/sj.tpj.6500401

Genes

TYMS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A novel G/C single-nucleotide polymorphism in the double 28-bp repeat thymidylate synthase allele.PMID 16868573Read ↗

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Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS).Semantic proximity Read ↗

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The prevalence and clinical relevance of 2R/2R TYMS genotype in patients with gastrointestinal malignancies treated with fluoropyrimidine-based chemotherapy regimens.Semantic proximity Read ↗

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