Resistance to Glycopeptide Antibiotics in the Teicoplanin Producer Is Mediated by <i>van</i> Gene Homologue Expression Directing the Synthesis of a Modified Cell Wall Peptidoglycan

Abstract excerpt

Glycopeptide resistance has been studied in detail in enterococci and staphylococci. In these microorganisms, high-level resistance is achieved by replacing the C-terminal D-alanyl-D-alanine of the nascent peptidoglycan with D-alanyl-D-lactate or D-alanyl-D-serine, thus reducing the affinities of glycopeptides for cell wall targets. Reorganization of the cell wall is directed by the expression of the van gene...

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