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Article

A novel membrane protein, VanJ, conferring resistance to teicoplanin.

Antimicrobial agents and chemotherapy - 1 Apr 2012

Novotna Gabriela, Hill Chris, Vincent Karen, Liu Chang, Hong Hee-Jeon

Abstract excerpt

Bacterial resistance to the glycopeptide antibiotic teicoplanin shows some important differences from the closely related compound vancomycin. They are currently poorly understood but may reflect significant differences in the mode of action of each antibiotic. Streptomyces coelicolor possesses a vanRSJKHAX gene cluster that when expressed confers resistance to both vancomycin and teicoplanin. The resistance to...

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Identifiers

PMID: 22232274
DOI: 10.1128/AAC.05869-11
PMCID: PMC3318380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel membrane protein, VanJ, conferring resistance to teicoplanin.PMID 22232274Read ↗

Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance.Semantic proximity Read ↗

Understanding the genome-wide response of Streptomyces coelicolor to the glycopeptide antibiotic teicoplaninSemantic proximity Read ↗

The role of the novel Fem protein VanK in vancomycin resistance in Streptomyces coelicolor.Semantic proximity Read ↗

Specific Inhibition of VanZ-Mediated Resistance to Lipoglycopeptide AntibioticsSemantic proximity Read ↗

Resistance to Glycopeptide Antibiotics in the Teicoplanin Producer Is Mediated by <i>van</i> Gene Homologue Expression Directing the Synthesis of a Modified Cell Wall PeptidoglycanSemantic proximity Read ↗

VanZ Reduces the Binding of Lipoglycopeptide Antibiotics to Staphylococcus aureus and Streptococcus pneumoniae CellsSemantic proximity Read ↗

Transcriptional response to vancomycin in a highly vancomycin-resistant Streptomyces coelicolor mutant.Semantic proximity Read ↗

Teicoplanin resistance in Staphylococcus haemolyticus is associated with mutations in histidine kinases VraS and WalK.Semantic proximity Read ↗

VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405.Semantic proximity Read ↗

The VanS sensor histidine kinase from type-B VRE recognizes vancomycin directlySemantic proximity Read ↗

Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component SystemSemantic proximity Read ↗

Characterization of VanYn, a novel D,D‐peptidase/D,D‐carboxypeptidase involved in glycopeptide antibiotic resistance in Nonomuraea sp. ATCC 39727Semantic proximity Read ↗

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