The functional <scp><i>vanG_Cd</i></scp> cluster of <i><scp>C</scp>lostridium difficile</i> does not confer vancomycin resistance

Abstract excerpt

vanGCd, a cryptic gene cluster highly homologous to the vanG gene cluster of Enterococcus faecalis is largely spread in Clostridium difficile. Since emergence of vancomycin resistance would have dramatic clinical consequences, we have evaluated the capacity of the vanGCd cluster to confer resistance. We showed that expression of vanGCd is inducible by vancomycin and that VanGCd , VanXYCd and VanTCd are...